비스포스포네이트 복용환자에서 발생한 악골괴사의 rhBMP-2 및 흡수성 atelocollagen sponge carrier를 사용한 치료: 증례보고
Treatment of osteonecrosis of the jaw in patients receiving bisphosphonates by application of recombinant human bone morphogenetic protein 2 and absorbable atelocollagen sponge carrier : A case report
손민호, 이의정, 박성준, 지남석, 현서정, 이수운,
소속 상세정보
손민호 ( Son Min-Ho ) - 인제대학교 의과대학 해운대백병원 구강악안면외과학교실
이의정 ( Lee Ui-Jeong ) - 인제대학교 의과대학 해운대백병원 구강악안면외과학교실
박성준 ( Park Seong-June ) - 인제대학교 의과대학 해운대백병원 구강악안면외과학교실
지남석 ( Chee Nam-Seok ) - 인제대학교 의과대학 해운대백병원 구강악안면외과학교실
현서정 ( Hyun Seo-Jeong ) - 인제대학교 의과대학 해운대백병원 구강악안면외과학교실
이수운 ( Lee Soo-Woon ) - 인제대학교 의과대학 해운대백병원 구강악안면외과학교실
KMID : 1033920140100010013
Abstract
Osteonecrosis of the jaws is the main complication in patients receiving bisphosphonates. This osteonecrosis is a
refractory disease despite the fact that consensus of treatment protocol is being established. In many studies,
recombinant human bone morphogenetic protein 2(rhBMP-2) has shown positive results in healing of bone defects.
The purpose of this case report is to analyze the clinical effect of rhBMP-2(Novosis??) infiltrated into absorbable
atelocollagen sponge(Teruplug??) application in osteonecrotic lesions of the jaw in 3 patients receiving bisphosphonates. A total dose of 0.5mg of rhBMP-2 was delivered in concentrations of 1mg/mL. The necrotic area has shown successful
healing and the patients did not show any symptom. We concluded that the application of rhBMP-2 is a earlier
therapeutic choice than AAOMS treatment protocol in bisphosphonates-related osteonecrosis of the jaw patients.
키워드
Bisphosphonate; Osteonecrosis; rhBMP-2; TERUPLUG
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